Cannabinoid-containing products may alter the effects of some prescription drugs, according to Penn State College of Medicine researchers.The researchers published information that could help medical professionals make safe prescribing choices for their patients who use prescription, over-the-counter or illicit cannabinoid products.
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This information included a list of enzymes in the body that process the active ingredients in those medications, which can include delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). They compared this information against prescribing information from common medications using information available from regulatory agencies like the U.S. Food and Drug Administration to identify where there may be overlap, called a drug-drug interaction. As one example, researchers identified warfarin, a common anticoagulant that prevents harmful blood clots from forming, as having a potential drug-drug interaction with cannabinoid products. Narrow Therapeutic Index Drug List Trial Fibrillation OrOften prescribed for patients with atrial fibrillation or following cardiac valve replacement, the drug has a narrow therapeutic index, and Vrana cautions that medical professionals consider this potential drug-drug interaction both when prescribing warfarin to patients on prescription cannabinoids or prescribing cannabinoids to a patient taking warfarin. Most of those products lack government regulation and there is little to no prescribing or drug-drug interaction information for those products. The drug-drug interaction information from medical cannabinoids may be useful as medical professionals consider the potential impact of over-the-counter or illicit cannabinoid products. He says that doing so can help ensure the safe and effective use of prescribed medications. Narrow Therapeutic Index Drug List Update This DrugVrana and Kocis plan to routinely update this drug-drug interaction list as newer medications are approved and real-world evidence accumulates. The College of Medicine and PA Options for Wellness have a 10-year research agreement designed to help physicians and patients make better informed clinical decisions related to cannabinoids.
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